New SBAs and EMQs on Hepatitis B in Pregnancy

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Question 1 of 4

1. Question
A 29 year old primiparous woman has antenatal screening for Hepatitis B at booking at 11 weeks gestation and has a positive result with positive HBsAg. She has confirmatory serology testing which shows:
- HBsAg positive
- Anti-HBs negative
- HBeAg positive
- Anti-HBe negative
- Anti-Hbc IgM negative
- Anti-Hbc IgG positive
- HBV DNA 270,867 IU/ml
What is the most appropriate management?
Commence tenofovir disoproxil immediately
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Commence tenofovir disoproxil at 16 to 20 weeks gestation
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Commence tenofovir disoproxil at 24 to 28 weeks gestation
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Commence tenofovir disoproxil at 32 to 36 weeks gestation
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Commence tenofovir disoproxil postnatally
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Question 2 of 4

2. Question

A 29-year-old pregnant woman is found to be hepatitis B surface antigen (HBsAg) positive at booking. Further serological testing is performed. Which of the following serological profiles is associated with the highest risk of vertical transmission of hepatitis B virus to the infant?

HBsAg positive, anti-HBc negative, anti-HBs negative
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HBsAg positive, anti-HBc positive, anti-HBs negative
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HBsAg positive, anti-HBc negative, anti-HBe negative
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HBsAg positive, HBeAg negative, anti-HBe positive
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HBsAg positive, HBeAg positive, anti-HBe negative
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Question 3 of 4

3. Question

A 29 year old primiparous woman is diagnosed with chronic hepatitis B infection during pregnancy with low HBV viral load <50 IU.ml. She has an uncomplicated vaginal birth at 38 weeks gestation with birthweight of 3.4kg. What is the most appropriate neonatal management?

Hepatitis B immunoglobulin (HBIG) within 24 hours of birth
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Hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine within 24 hours of birth
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Hepatitis B immunoglobulin (HBIG) at 6 weeks after birth
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Hepatitis B vaccine delayed until 6 weeks
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Hepatitis B vaccine only if mother is symptomatic
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Hepatitis B vaccine plus Hepatitis B immunoglobulin (HBIG) at 7 days after birth
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Hepatitis B vaccine within 24 hours of birth
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No intervention required
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Start neonatal antiviral therapy within 24 hours of birth
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Question 4 of 4

4. Question

A 29 year old primiparous woman is diagnosed with chronic hepatitis B infection during pregnancy with low HBV viral load <50 IU.ml. She presents in spontaneous preterm labour at 30 weeks gestation and has an uncomplicated vaginal birth with birthweight of 1.5kg. What is the most appropriate neonatal management?

Hepatitis B immunoglobulin (HBIG) within 24 hours of birth
Correct Incorrect Correct answer

Hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine within 24 hours of birth
Correct Incorrect Correct answer

Hepatitis B immunoglobulin (HBIG) at 6 weeks after birth
Correct Incorrect Correct answer

Hepatitis B vaccine delayed until 6 weeks
Correct Incorrect Correct answer

Hepatitis B vaccine only if mother is symptomatic
Correct Incorrect Correct answer

Hepatitis B vaccine plus Hepatitis B immunoglobulin (HBIG) at 7 days after birth
Correct Incorrect Correct answer

Hepatitis B vaccine within 24 hours of birth
Correct Incorrect Correct answer

No intervention required
Correct Incorrect Correct answer

Start neonatal antiviral therapy within 24 hours of birth
Correct Incorrect Correct answer

Correct

Incorrect

New SBAs and EMQs on Hepatitis B in Pregnancy

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